Toll-like receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBFB, ASH2L, and EIF4H, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll-like receptor signaling pathway activity versus CBFB in OVARY (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CBFB →	-1.167	-0.248	.001	.005	2	7
LARGE_INTESTINE	ASH2L →	-0.631	-0.171	.001	.002	3	6
OVARY	EIF4H →	-0.665	-0.261	.006	.001	3	5
OVARY	MRPL19 →	-0.667	-0.264	.003	.006	3	5
LUNG_SCLC	UBR7 →	-0.808	-0.112	<.001	.004	3	5
SKIN	AATF →	-0.545	-0.277	.004	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002224 vs CBFB — OVARY

Explore this scatter interactively →