Activation of innate immune response

Across TCGA patient cohorts, RNA activity of the Activation of innate immune response pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STK10, THEMIS2_T593, and WIPF1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of innate immune response activity versus STK10 in GBM (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STK10 →	+0.549	+0.058	<.001	<.001	3	10
CCRCC	THEMIS2_T593 →	+0.837	+0.032	<.001	<.001	3	10
LSCC	WIPF1 →	+0.388	+0.048	<.001	<.001	3	10
LSCC	BTK →	+0.558	+0.056	<.001	<.001	3	10
LSCC	CCDC88B_S597 →	+0.711	+0.052	<.001	<.001	3	10
OV	ADPRH →	+0.467	+0.046	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002218 vs STK10 — GBM

Explore this scatter interactively →