Activation of innate immune response

Across TCGA cell cohorts, RNA activity of the Activation of innate immune response pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQOR, TAPBP, and MVP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of innate immune response activity versus SQOR in STOMACH (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SQOR →	-3.055	-0.215	.004	.002	3	9
LIVER	TAPBP →	-1.557	-0.345	.008	<.001	3	8
BREAST	MVP →	-2.164	-0.191	<.001	<.001	3	8
SOFT_TISSUE	SERPINB1 →	-3.096	-0.194	.001	.005	3	7
BLOOD_Lymphoma	TRIM21 →	-1.242	-0.182	<.001	<.001	3	7
BLOOD_Lymphoma	FEM1C →	-0.787	-0.146	.003	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002218 vs SQOR — STOMACH

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