Somatic diversification of immune receptors

Across TCGA cell cohorts, RNA activity of the Somatic diversification of immune receptors pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNTN1, SLC45A4, and AKAP5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNTN1 grouped by Somatic diversification of immune receptors-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CNTN1 →	+2.174	+0.301	.002	.001	3	4
LUNG_NSCLC_LUAD	SLC45A4 →	+0.967	+0.125	<.001	<.001	3	4
CNS	AKAP5 →	+0.769	+0.213	.001	<.001	3	4
SOFT_TISSUE	VARS2 →	+0.992	+0.373	.005	<.001	3	4
LARGE_INTESTINE	S100PBP →	+0.679	+0.146	<.001	.002	3	4
LARGE_INTESTINE	PCMT1 →	-0.579	-0.166	.007	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNTN1 by Somatic diversification of immune receptors activity — BLOOD_Myeloma

Explore this box plot interactively →