Cap-dependent translational initiation

Across TCGA patient cohorts, RNA activity of the Cap-dependent translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHYHIP, IQSEC3, and PTH1R, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cap-dependent translational initiation activity versus PHYHIP in GBM (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PHYHIP →	-0.795	-0.098	.004	.003	3	7
OV	IQSEC3 →	-1.072	-0.222	<.001	.003	3	4
CCRCC	PTH1R →	-1.056	-0.135	.001	.009	2	5
CCRCC	FAM107A →	-0.819	-0.173	<.001	<.001	3	4
COAD	BUB1 →	+0.518	+0.175	<.001	.002	3	4
CCRCC	TNS2 →	-0.566	-0.148	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002191 vs PHYHIP — GBM

Explore this scatter interactively →