Cap-dependent translational initiation

Across TCGA cell cohorts, RNA activity of the Cap-dependent translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STARD9, SET, and TMBIM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cap-dependent translational initiation activity versus STARD9 in LARGE_INTESTINE (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	STARD9 →	+0.765	+0.793	<.001	.002	3	7
BLOOD_Leukemia	SET →	+0.634	+0.172	<.001	.005	3	7
BLOOD_Leukemia	TMBIM1 →	-1.879	-0.206	<.001	.001	3	7
LUNG_SCLC	PSIP1 →	+1.269	+0.453	.003	.002	3	6
LUNG_SCLC	GKAP1 →	+1.020	+0.254	.001	.007	3	6
BLOOD_Lymphoma	TNFRSF13C →	+2.335	+0.243	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002191 vs STARD9 — LARGE_INTESTINE

Explore this scatter interactively →