Cytoplasmic translational initiation

Across TCGA patient cohorts, RNA activity of the Cytoplasmic translational initiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LCN2, UBTF, and DCLK2_T683, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoplasmic translational initiation activity versus LCN2 in LSCC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LCN2 →	-0.958	-0.045	<.001	<.001	3	6
LSCC	UBTF →	+0.329	+0.040	<.001	<.001	3	5
PDAC	DCLK2_T683 →	+1.051	+0.037	.001	.001	3	5
LSCC	HCFC1 →	+0.198	+0.040	<.001	<.001	3	5
LSCC	PTBP2 →	+1.178	+0.046	<.001	<.001	3	5
LSCC	RAB3D →	-0.419	-0.032	.003	.009	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002183 vs LCN2 — LSCC

Explore this scatter interactively →