Cytoplasmic translational elongation

Across TCGA patient cohorts, RNA activity of the Cytoplasmic translational elongation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NEMF, RALGAPA1, and NAA35, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoplasmic translational elongation activity versus NEMF in GBM (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NEMF →	+0.233	+0.065	<.001	<.001	3	7
GBM	RALGAPA1 →	+0.250	+0.055	<.001	.002	3	6
HNSC	NAA35 →	+0.164	+0.048	.002	.008	3	5
BRCA	CDC42BPB →	+0.360	+0.047	<.001	<.001	3	5
GBM	GMFB →	+0.490	+0.073	<.001	<.001	3	5
BRCA	RAC2 →	-0.604	-0.044	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002182 vs NEMF — GBM

Explore this scatter interactively →