Cytoplasmic translational elongation

Across TCGA patient cohorts, RNA activity of the Cytoplasmic translational elongation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP94, SPOP, and DOK5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoplasmic translational elongation activity versus CFAP94 in BRCA (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CFAP94 →	-0.622	-0.089	.001	.007	3	5
BRCA	SPOP →	-0.572	-0.148	<.001	<.001	3	4
UCEC	DOK5 →	-0.893	-0.159	.001	.001	3	3
UCEC	FAM20A →	-0.717	-0.124	<.001	.006	3	3
UCEC	ZBTB46 →	-0.381	-0.151	.006	.001	3	3
OV	C11orf16 →	-0.542	-0.820	.008	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002182 vs CFAP94 — BRCA

Explore this scatter interactively →