Cytoplasmic translational elongation

Across TCGA cell cohorts, RNA activity of the Cytoplasmic translational elongation pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VRK1, BIRC2, and MORN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VRK1 grouped by Cytoplasmic translational elongation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	VRK1 →	+0.245	+1.019	.004	.003	3	3
OVARY	BIRC2 →	+0.225	+0.981	<.001	.004	3	3
SOFT_TISSUE	MORN3 →	+0.207	+0.160	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	CDK9 →	+0.164	+0.171	.002	.003	3	3
UPPER_AERODIGESTIVE_TRACT	PSG6 →	+0.123	+0.171	.005	.003	3	3
UPPER_AERODIGESTIVE_TRACT	FNDC3B →	+0.221	+0.163	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VRK1 by Cytoplasmic translational elongation activity — OVARY

Explore this box plot interactively →