Cytoplasmic translational elongation

Across TCGA cell cohorts, RNA activity of the Cytoplasmic translational elongation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UFL1, SEL1L, and FAM120B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoplasmic translational elongation activity versus UFL1 in BLOOD_Leukemia (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UFL1 →	+0.882	+0.143	.002	.005	3	6
BLOOD_Myeloma	SEL1L →	+1.489	+0.123	.001	.005	3	4
BLOOD_Lymphoma	FAM120B →	+0.529	+0.149	.001	<.001	3	4
BLOOD_Lymphoma	FASN →	+1.012	+0.138	<.001	.001	3	4
BLOOD_Lymphoma	FICD →	+0.828	+0.173	.003	<.001	3	4
KIDNEY	ETV1 →	+1.266	+0.126	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002182 vs UFL1 — BLOOD_Leukemia

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