Cytoplasmic translation

Across TCGA patient cohorts, RNA activity of the Cytoplasmic translation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL18A_S123, CACNA2D1, and COL18A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoplasmic translation activity versus RPL18A_S123 in HNSC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL18A_S123 →	-0.549	-0.118	<.001	.001	3	6
COAD	CACNA2D1 →	+0.526	+0.028	<.001	<.001	3	6
COAD	COL18A1 →	+0.309	+0.020	.007	.006	3	6
CCRCC	ABI3BP →	+1.101	+0.049	<.001	<.001	3	6
COAD	HDGFL3 →	+0.612	+0.028	.001	<.001	3	6
HNSC	EPM2AIP1 →	+0.282	+0.089	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002181 vs RPL18A_S123 — HNSC

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