Thyroid hormone mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Thyroid hormone mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NRBF2, RXRA, and S100A9_T113, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thyroid hormone mediated signaling pathway activity versus NRBF2 in HNSC (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NRBF2 →	-0.265	-0.064	.001	.002	3	6
BRCA	RXRA →	+0.317	+0.051	<.001	<.001	3	6
HNSC	S100A9_T113 →	-0.570	-0.057	.001	.009	3	5
BRCA	TRIOBP →	+0.283	+0.053	.001	<.001	3	5
BRCA	G3BP1 →	-0.182	-0.044	.001	<.001	3	5
BRCA	RPL3 →	-0.205	-0.031	.004	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002154 vs NRBF2 — HNSC

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