Aggressive behavior

Across TCGA patient cohorts, RNA activity of the Aggressive behavior pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLG, HMGN2P25, and DYNLT3P1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aggressive behavior activity versus PLG in BRCA (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLG →	+0.174	+0.168	.003	.005	3	2
BRCA	HMGN2P25 →	+1.554	+0.348	.003	.008	3	2
BRCA	DYNLT3P1 →	+1.570	+0.194	.001	.001	3	2
BRCA	FAM218A →	+1.217	+0.188	<.001	<.001	3	2
UCEC	GPR17 →	-1.576	-0.331	.001	.007	3	2
UCEC	RPS20P5 →	+1.041	+0.244	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002118 vs PLG — BRCA

Explore this scatter interactively →