Aggressive behavior

Across TCGA cell cohorts, RNA activity of the Aggressive behavior pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AVP, TACR1, and KIRREL3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AVP grouped by Aggressive behavior-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	AVP →	-0.186	-1.162	.004	.003	3	8
CNS	TACR1 →	-0.224	-0.917	.001	.001	2	8
BONE	KIRREL3 →	-0.161	-1.630	.009	.001	3	7
OVARY	AVPR1A →	-0.268	-1.411	<.001	.002	3	7
LUNG_NSCLC_LUAD	NR2E1 →	-0.121	-0.825	<.001	.001	3	7
LUNG_SCLC	CLDN4 →	-0.226	-1.156	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AVP by Aggressive behavior activity — KIDNEY

Explore this box plot interactively →