Aggressive behavior

Across TCGA cell cohorts, RNA activity of the Aggressive behavior pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB3GAP2, SERGEF, and MTPAP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB3GAP2 grouped by Aggressive behavior-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RAB3GAP2 →	+0.465	+1.715	.001	<.001	3	4
BLOOD_Leukemia	SERGEF →	-0.602	-1.157	.001	.005	3	4
STOMACH	MTPAP →	+1.087	+1.671	<.001	<.001	3	4
BLOOD_Myeloma	KCTD3 →	+1.325	+1.735	.003	<.001	3	4
BLOOD_Myeloma	FEM1B →	+1.030	+1.866	.002	<.001	3	4
BLOOD_Myeloma	ATG4D →	+1.019	+1.442	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB3GAP2 by Aggressive behavior activity — BONE

Explore this box plot interactively →