tRNA wobble base modification

Across TCGA patient cohorts, RNA activity of the tRNA wobble base modification pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDK5, NANOGP1, and RNU6-917P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA wobble base modification activity versus CDK5 in UCEC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDK5 →	+0.688	+0.239	<.001	<.001	3	4
LUAD	NANOGP1 →	+0.260	+0.171	.002	<.001	3	3
LUAD	RNU6-917P →	-0.877	-0.187	<.001	<.001	3	3
UCEC	PCK2 →	+0.572	+0.138	.001	.007	3	3
UCEC	AGAP3 →	+0.351	+0.176	.002	.005	3	3
UCEC	TACO1 →	+0.597	+0.198	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002097 vs CDK5 — UCEC

Explore this scatter interactively →