tRNA wobble base modification

Across TCGA cell cohorts, RNA activity of the tRNA wobble base modification pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLIRP, CCDC58, and LYAR, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA wobble base modification activity versus SLIRP in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SLIRP →	+1.120	+0.063	.006	.003	3	17
BONE	CCDC58 →	+0.890	+0.076	<.001	<.001	3	17
LIVER	LYAR →	+1.319	+0.099	<.001	.001	3	16
BLOOD_Lymphoma	RPF2 →	+1.147	+0.046	<.001	<.001	3	15
BREAST	NOP16 →	+0.895	+0.067	<.001	<.001	3	15
SOFT_TISSUE	NOP58 →	+0.731	+0.060	.003	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002097 vs SLIRP — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →