Auditory receptor cell morphogenesis

Across TCGA cell cohorts, RNA activity of the Auditory receptor cell morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NBAS, LEPR, and NUAK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Auditory receptor cell morphogenesis activity versus NBAS in PANCREAS (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NBAS →	-0.661	-1.400	.001	.001	3	4
CNS	LEPR →	-1.154	-1.712	.009	<.001	2	5
CNS	NUAK1 →	-1.481	-1.279	.003	.001	3	4
LUNG_NSCLC_LUAD	TWSG1 →	-0.984	-1.158	.001	.001	3	4
LUNG_NSCLC_LUAD	TSPYL4 →	-0.791	-0.803	.001	.006	3	4
OVARY	TUFT1 →	-1.392	-0.892	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002093 vs NBAS — PANCREAS

Explore this scatter interactively →