Positive regulation of receptor internalization

Across TCGA patient cohorts, RNA activity of the Positive regulation of receptor internalization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN6, SBSPON, and FGL2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor internalization activity versus SEPTIN6 in GBM (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN6 →	+0.403	+0.051	<.001	.001	3	7
OV	SBSPON →	+0.622	+0.035	<.001	<.001	3	6
CCRCC	FGL2 →	+0.639	+0.038	<.001	.001	3	6
LSCC	LCP1 →	+0.381	+0.077	<.001	<.001	3	6
LSCC	ACAP1_T739 →	+0.666	+0.075	<.001	<.001	3	6
LSCC	PKP3_S331 →	-0.531	-0.060	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002092 vs SEPTIN6 — GBM

Explore this scatter interactively →