Positive regulation of receptor internalization

Across TCGA patient cohorts, RNA activity of the Positive regulation of receptor internalization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRR1, FAM32BP, and DAB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor internalization activity versus LRR1 in HNSC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LRR1 →	-0.620	-0.112	<.001	.007	3	4
UCEC	FAM32BP →	+0.891	+0.236	.001	<.001	3	4
LSCC	DAB2 →	+0.596	+0.134	.005	.005	3	3
LSCC	PODN →	+0.670	+0.145	.002	.001	3	3
LSCC	TMEM119 →	+0.599	+0.144	.005	.002	3	3
LSCC	ITGBL1 →	+0.665	+0.127	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002092 vs LRR1 — HNSC

Explore this scatter interactively →