Positive regulation of receptor internalization

Across TCGA cell cohorts, RNA activity of the Positive regulation of receptor internalization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMP2, SNAI2, and IGFBP6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor internalization activity versus TIMP2 in LARGE_INTESTINE (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TIMP2 →	-1.833	-0.109	.005	<.001	3	8
LUNG_NSCLC_LUSC	SNAI2 →	-3.718	-0.165	.001	.001	3	8
LIVER	IGFBP6 →	-2.771	-0.143	.004	.001	3	8
STOMACH	GSDME →	-2.132	-0.126	.002	<.001	3	7
LUNG_NSCLC_LUAD	LRRC8B →	+0.968	+0.075	<.001	<.001	3	7
STOMACH	HSPB8 →	-2.464	-0.115	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002092 vs TIMP2 — LARGE_INTESTINE

Explore this scatter interactively →