Positive regulation of receptor internalization

Across TCGA cell cohorts, RNA activity of the Positive regulation of receptor internalization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC15A3, FAM136A, and MARS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor internalization activity versus SLC15A3 in BLOOD_Lymphoma (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC15A3 →	+2.568	+1.283	.003	<.001	3	5
LIVER	FAM136A →	-1.081	-1.439	<.001	.002	3	5
SOFT_TISSUE	MARS2 →	-1.009	-1.531	.004	.002	3	5
CNS	CEBPZ →	-0.616	-1.163	.004	.004	3	5
BLOOD_Lymphoma	NCOA3 →	+1.288	+1.249	<.001	<.001	3	5
LARGE_INTESTINE	ATP5MC3 →	-0.658	-0.965	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002092 vs SLC15A3 — BLOOD_Lymphoma

Explore this scatter interactively →