Lens morphogenesis in camera-type eye

Across TCGA cell cohorts, RNA activity of the Lens morphogenesis in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OSGEPL1, NIF3L1, and ASB3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lens morphogenesis in camera-type eye activity versus OSGEPL1 in CNS (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OSGEPL1 →	-0.638	-0.262	.009	.005	3	5
PANCREAS	NIF3L1 →	-0.692	-0.250	<.001	<.001	3	5
BREAST	ASB3 →	-0.898	-0.300	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF644 →	-0.922	-0.418	.002	.002	3	4
UPPER_AERODIGESTIVE_TRACT	ZFP69B →	-0.664	-0.499	.001	.007	3	4
UPPER_AERODIGESTIVE_TRACT	ERLEC1 →	-0.839	-0.665	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002089 vs OSGEPL1 — CNS

Explore this scatter interactively →