Regulation of respiratory gaseous exchange by nervous system process

Across TCGA patient cohorts, RNA activity of the Regulation of respiratory gaseous exchange by nervous system process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DNM1, COL1A1, and SRPX2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of respiratory gaseous exchange by nervous system process activity versus DNM1 in LSCC (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DNM1 →	+0.440	+0.079	<.001	<.001	3	8
LUAD	COL1A1 →	+0.652	+0.077	<.001	<.001	3	8
HNSC	SRPX2 →	+0.599	+0.137	<.001	<.001	2	8
LSCC	C1S →	+0.583	+0.110	<.001	<.001	3	7
COAD	FAP →	+0.709	+0.026	<.001	.001	3	7
UCEC	ISLR →	+0.625	+0.119	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002087 vs DNM1 — LSCC

Explore this scatter interactively →