Regulation of respiratory gaseous exchange by nervous system process

Across TCGA patient cohorts, RNA activity of the Regulation of respiratory gaseous exchange by nervous system process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRCA1, GMPS, and FANCE, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of respiratory gaseous exchange by nervous system process activity versus BRCA1 in LSCC (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BRCA1 →	-0.868	-0.917	<.001	<.001	3	6
LSCC	GMPS →	-0.551	-0.589	<.001	<.001	3	6
LSCC	FANCE →	-0.791	-0.673	<.001	<.001	3	6
LSCC	MCM6 →	-0.732	-1.020	<.001	<.001	3	6
LSCC	ACACA →	-0.461	-0.710	<.001	<.001	3	6
BRCA	STK38 →	-0.517	-0.554	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002087 vs BRCA1 — LSCC

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