Regulation of oxidative phosphorylation

Across TCGA patient cohorts, RNA activity of the Regulation of oxidative phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NKX3-1, FAM171A1, and CCDC141, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of oxidative phosphorylation activity versus NKX3-1 in COAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NKX3-1 →	-0.573	-0.129	.003	.005	3	4
LUAD	FAM171A1 →	-0.535	-0.118	.007	.007	3	3
PDAC	CCDC141 →	-0.471	-0.099	<.001	.009	3	3
PDAC	RIC3 →	-0.809	-0.178	<.001	<.001	3	3
COAD	PIGN →	-0.375	-0.133	.004	.001	2	4
PDAC	RAET1G →	+0.555	+0.119	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002082 vs NKX3-1 — COAD

Explore this scatter interactively →