Regulation of oxidative phosphorylation

Across TCGA patient cohorts, RNA activity of the Regulation of oxidative phosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COX5A, COX7A2, and SYDE1_S683, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of oxidative phosphorylation activity versus COX5A in UCEC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX5A →	+0.472	+0.164	<.001	<.001	3	4
UCEC	COX7A2 →	+0.804	+0.225	<.001	.003	3	4
CCRCC	SYDE1_S683 →	-0.542	-0.247	<.001	<.001	3	4
COAD	UQCC1 →	+0.363	+0.127	<.001	.001	3	4
OV	SRRM2_S1101 →	-0.968	-0.210	<.001	<.001	3	3
UCEC	UQCRC1 →	+0.442	+0.154	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002082 vs COX5A — UCEC

Explore this scatter interactively →