Regulation of oxidative phosphorylation

Across TCGA cell cohorts, RNA activity of the Regulation of oxidative phosphorylation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VCP, SLC4A4, and SH2B1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VCP grouped by Regulation of oxidative phosphorylation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	VCP →	-0.875	-0.432	<.001	.009	3	9
LUNG_NSCLC_LUSC	SLC4A4 →	-0.193	-1.555	.002	.003	3	5
BLOOD_Leukemia	SH2B1 →	+0.261	+0.258	<.001	<.001	3	4
PANCREAS	COX7C →	+0.228	+0.290	.001	<.001	3	3
LUNG_SCLC	DGCR6L →	-0.182	-0.207	.005	.005	3	3
LUNG_SCLC	SCGN →	-0.151	-0.293	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VCP by Regulation of oxidative phosphorylation activity — SKIN

Explore this box plot interactively →