Regulation of oxidative phosphorylation

Across TCGA cell cohorts, RNA activity of the Regulation of oxidative phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF24, UBE2R2, and UBAP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF24 grouped by Regulation of oxidative phosphorylation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KIF24 →	-0.310	-0.287	.001	.008	3	6
PANCREAS	UBE2R2 →	-0.727	-0.280	.003	.003	3	4
PANCREAS	UBAP2 →	-0.988	-0.273	.001	.008	3	4
OESOPHAGUS	SMU1 →	-0.574	-0.244	.001	<.001	3	4
OESOPHAGUS	UBAP1 →	-0.664	-0.198	.009	.006	2	5
OESOPHAGUS	DCAF12 →	-0.899	-0.256	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF24 by Regulation of oxidative phosphorylation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →