Osteoblast development

Across TCGA patient cohorts, RNA activity of the Osteoblast development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP9, SPON2, and SCAF4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Osteoblast development activity versus FKBP9 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FKBP9 →	+0.387	+0.027	<.001	<.001	3	7
OV	SPON2 →	+0.696	+0.025	.002	.005	3	7
BRCA	SCAF4 →	-0.254	-0.027	<.001	<.001	3	5
PDAC	C1R →	+0.485	+0.048	<.001	<.001	3	5
BRCA	ITGB5 →	+0.427	+0.030	<.001	<.001	3	5
BRCA	SH3PXD2B →	+0.332	+0.038	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002076 vs FKBP9 — BRCA

Explore this scatter interactively →