Osteoblast development

Across TCGA patient cohorts, RNA activity of the Osteoblast development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFRP4, XYLT2, and LINC01315, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Osteoblast development activity versus SFRP4 in OV (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SFRP4 →	+1.418	+0.184	.001	.004	3	4
BRCA	XYLT2 →	+0.566	+0.626	.001	.001	3	4
HNSC	LINC01315 →	+0.541	+0.171	.005	.003	3	4
PDAC	IGFBP6 →	+0.499	+0.268	.007	.009	3	4
LSCC	MYRFL →	-0.346	-0.176	.007	.008	3	3
COAD	SLC35D1 →	+0.389	+0.314	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002076 vs SFRP4 — OV

Explore this scatter interactively →