Osteoblast development

Across TCGA cell cohorts, RNA activity of the Osteoblast development pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO48, TAPT1, and WDCP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXO48 grouped by Osteoblast development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FBXO48 →	+0.463	+1.117	.002	.003	3	4
KIDNEY	TAPT1 →	+1.377	+1.633	.001	.001	3	4
BLOOD_Leukemia	WDCP →	+0.879	+1.075	.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	SS18L2 →	-1.231	-1.350	.006	.009	3	4
SOFT_TISSUE	ERRFI1 →	+3.811	+1.779	<.001	<.001	3	3
SKIN	STX11 →	-1.345	-1.047	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXO48 by Osteoblast development activity — PANCREAS

Explore this box plot interactively →