Optic cup morphogenesis involved in camera-type eye development

Across TCGA patient cohorts, RNA activity of the Optic cup morphogenesis involved in camera-type eye development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD4, PTGER4, and ZDHHC18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Optic cup morphogenesis involved in camera-type eye development activity versus CD4 in LUAD (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CD4 →	+0.393	+0.704	.006	<.001	3	4
BRCA	PTGER4 →	+0.806	+0.369	<.001	<.001	3	4
OV	ZDHHC18 →	+0.485	+0.811	<.001	<.001	3	4
LUAD	LPXN →	+0.306	+0.816	.001	<.001	3	3
LUAD	CTBS →	+0.246	+0.727	.006	<.001	3	3
BRCA	BACH1 →	+0.423	+0.250	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002072 vs CD4 — LUAD

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