Optic cup morphogenesis involved in camera-type eye development

Across TCGA cell cohorts, RNA activity of the Optic cup morphogenesis involved in camera-type eye development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNG10, MIPEP, and SMURF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GNG10 grouped by Optic cup morphogenesis involved in camera-type eye development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GNG10 →	-0.652	-0.686	.002	.004	3	4
BREAST	MIPEP →	+0.751	+0.683	.002	.006	3	4
PANCREAS	SMURF2 →	-1.150	-0.963	.001	.001	3	4
PANCREAS	CASZ1 →	+1.089	+0.884	.001	.003	3	3
LARGE_INTESTINE	TMEM164 →	+0.750	+0.909	.001	<.001	3	3
LARGE_INTESTINE	PLA2G2A →	+2.237	+0.840	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GNG10 by Optic cup morphogenesis involved in camera-type eye development activity — LARGE_INTESTINE

Explore this box plot interactively →