Optic cup morphogenesis involved in camera-type eye development

Across TCGA cell cohorts, RNA activity of the Optic cup morphogenesis involved in camera-type eye development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFAP2A, PHACTR4, and DSCC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Optic cup morphogenesis involved in camera-type eye development activity versus TFAP2A in OVARY (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TFAP2A →	+2.585	+0.219	<.001	.001	3	8
BLOOD_Leukemia	PHACTR4 →	+1.047	+0.450	<.001	<.001	3	7
URINARY_TRACT	DSCC1 →	-0.789	-0.202	.009	.001	3	5
LUNG_NSCLC_LUAD	RPH3AL →	-1.242	-0.146	.001	.004	3	5
SKIN	DOK1 →	-1.121	-0.169	.001	<.001	3	4
SKIN	ADGRL2 →	-1.528	-0.111	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002072 vs TFAP2A — OVARY

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