Glandular epithelial cell maturation

pathway activity — cross-omics
GO:0002071Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Glandular epithelial cell maturation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPAR5, RAP2B, and ADGRF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECLPAR5 →-0.627-0.606.001.00634
HNSCRAP2B →-0.508-0.226.001.00134
LUADADGRF1 →-1.658-0.289<.001<.00134
UCECCOQ4 →+0.488+0.964.004<.00134
BRCABAIAP2L1 →-0.644-0.729.004<.00134
LUADSLC25A23 →-0.381-0.219.009.00833
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration