Epithelial cell maturation

Across TCGA patient cohorts, RNA activity of the Epithelial cell maturation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PGR_S400, TSHZ2_S332, and CELF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell maturation activity versus PGR_S400 in BRCA (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PGR_S400 →	+1.623	+0.775	<.001	<.001	3	3
UCEC	TSHZ2_S332 →	-0.646	-0.652	<.001	.001	3	3
LSCC	CELF2 →	-0.369	-0.317	<.001	<.001	3	3
OV	IRS2_S1203 →	+1.205	+0.755	<.001	<.001	3	3
COAD	MYH11_S1722 →	-0.561	-0.694	.004	<.001	3	3
COAD	MYH11_S1729 →	-0.561	-0.694	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002070 vs PGR_S400 — BRCA

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