Epithelial cell maturation

Across TCGA cell cohorts, RNA activity of the Epithelial cell maturation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf167, SMARCD3, and CDK5RAP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1orf167 grouped by Epithelial cell maturation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1orf167 →	+0.855	+1.198	<.001	<.001	3	4
SOFT_TISSUE	SMARCD3 →	+1.658	+2.003	.001	<.001	3	4
BONE	CDK5RAP3 →	+0.876	+1.034	<.001	.008	3	4
LUNG_NSCLC_LUSC	ZC3H6 →	+0.714	+1.096	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	DDR1 →	-1.928	-1.404	<.001	.001	3	4
SKIN	WDR82 →	+0.356	+0.983	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1orf167 by Epithelial cell maturation activity — LARGE_INTESTINE

Explore this box plot interactively →