Epithelial cell maturation

Across TCGA cell cohorts, RNA activity of the Epithelial cell maturation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDPK1, SP5, and WASH8P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDPK1 grouped by Epithelial cell maturation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PDPK1 →	+0.340	+0.839	.001	.004	3	4
BREAST	SP5 →	+0.116	+0.794	.001	.003	3	4
BLOOD_Leukemia	WASH8P →	-0.168	-1.398	<.001	<.001	3	3
OESOPHAGUS	ORM2 →	-0.168	-0.906	.003	.006	3	3
LUNG_NSCLC_LUSC	FAF2 →	+0.238	+0.754	.004	.009	3	3
SKIN	ACTR2 →	-0.202	-0.110	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDPK1 by Epithelial cell maturation activity — BREAST

Explore this box plot interactively →