Epithelial cell development

Across TCGA cell cohorts, RNA activity of the Epithelial cell development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR93, FAM98A, and ATXN7L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR93 grouped by Epithelial cell development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WDR93 →	-0.186	-0.228	.006	.004	3	4
URINARY_TRACT	FAM98A →	+0.753	+0.241	<.001	<.001	3	3
LARGE_INTESTINE	ATXN7L1 →	+0.723	+0.307	<.001	<.001	3	3
BLOOD_Leukemia	TSR1 →	+0.907	+0.645	<.001	.004	3	3
OESOPHAGUS	SYNPO →	-1.580	-0.686	.003	.006	3	3
OESOPHAGUS	TUBB6 →	-1.539	-0.937	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR93 by Epithelial cell development activity — LARGE_INTESTINE

Explore this box plot interactively →