Chondrocyte development

Across TCGA patient cohorts, RNA activity of the Chondrocyte development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, RUNX2_S28, and SFRP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondrocyte development activity versus RSU1 in OV (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RSU1 →	+0.425	+0.097	<.001	<.001	3	9
OV	RUNX2_S28 →	+0.934	+0.079	<.001	<.001	3	9
OV	SFRP2 →	+1.856	+0.092	<.001	<.001	3	9
GBM	TGFBI →	+0.606	+0.051	<.001	<.001	3	9
PDAC	VIM →	+0.533	+0.079	<.001	<.001	3	9
BRCA	BGN →	+0.757	+0.042	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002063 vs RSU1 — OV

Explore this scatter interactively →