Chondrocyte development

Across TCGA patient cohorts, RNA activity of the Chondrocyte development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOXL2, COL5A1, and ACTA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondrocyte development activity versus LOXL2 in BRCA (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LOXL2 →	+1.652	+1.306	<.001	<.001	3	6
BRCA	COL5A1 →	+1.890	+1.241	<.001	<.001	3	6
OV	ACTA2 →	+1.430	+0.840	.006	.004	3	5
BRCA	COL1A1 →	+2.054	+1.184	<.001	<.001	3	5
BRCA	NKX3-2 →	+0.975	+1.012	<.001	<.001	3	5
OV	ID3 →	+1.194	+1.061	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002063 vs LOXL2 — BRCA

Explore this scatter interactively →