Chondrocyte development

Across TCGA cell cohorts, RNA activity of the Chondrocyte development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNNI1, NGEF, and SCAMP5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNNI1 grouped by Chondrocyte development-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TNNI1 →	+7.603	+1.986	<.001	<.001	3	4
OVARY	NGEF →	+2.316	+0.941	.002	.002	3	4
BLOOD_Lymphoma	SCAMP5 →	+4.462	+1.867	<.001	<.001	3	3
KIDNEY	PPP1R3D →	+0.667	+0.948	.002	<.001	3	3
KIDNEY	CTSL →	+1.198	+0.922	<.001	.001	3	3
KIDNEY	SSBP3 →	+1.520	+1.361	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNNI1 by Chondrocyte development activity — BLOOD_Lymphoma

Explore this box plot interactively →