Chondrocyte development

Across TCGA cell cohorts, RNA activity of the Chondrocyte development pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are UNC0642, N23918-95-7, and Luminespib, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UNC0642 grouped by Chondrocyte development-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UNC0642 →	+0.103	+0.501	.042	<.001	3	2
LARGE_INTESTINE	N23918-95-7 →	+0.396	+0.259	.013	.010	3	2
LARGE_INTESTINE	Luminespib →	-0.870	-0.259	.026	.010	3	2
LARGE_INTESTINE	OF-1 →	-0.780	-0.259	.030	.010	3	2
BLOOD_Lymphoma	Rapamycin →	-1.263	-1.832	.022	<.001	3	1
BLOOD_Lymphoma	Oxaliplatin →	+0.898	+1.260	.004	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UNC0642 by Chondrocyte development activity — BLOOD_Leukemia

Explore this box plot interactively →