Chondrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Chondrocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINF1, SRPX2, and TLN1_T1263, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondrocyte differentiation activity versus SERPINF1 in OV (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPINF1 →	+1.045	+0.061	<.001	<.001	3	10
BRCA	SRPX2 →	+0.762	+0.026	<.001	<.001	3	10
UCEC	TLN1_T1263 →	+0.714	+0.054	.005	.004	3	10
OV	VCAN_S2116 →	+1.236	+0.061	<.001	<.001	3	10
OV	VCL_S795 →	+0.700	+0.040	.006	.008	3	10
UCEC	BGN →	+0.940	+0.065	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002062 vs SERPINF1 — OV

Explore this scatter interactively →