Chondrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Chondrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRMD6, BMP1, and ADAM9, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondrocyte differentiation activity versus FRMD6 in BONE (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FRMD6 →	+2.348	+0.125	<.001	<.001	3	11
LUNG_NSCLC_LUSC	BMP1 →	+2.020	+0.118	<.001	<.001	3	10
BREAST	ADAM9 →	+1.670	+0.069	<.001	.005	2	11
LUNG_NSCLC_LUSC	RUNX2 →	+2.514	+0.137	<.001	.002	2	11
LUNG_SCLC	ELK3 →	+1.776	+0.079	<.001	<.001	3	10
LUNG_SCLC	RRAS →	+2.668	+0.099	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002062 vs FRMD6 — BONE

Explore this scatter interactively →