Chondrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Chondrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPRYD7, NDUFS1, and RAB27A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondrocyte differentiation activity versus SPRYD7 in OVARY (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SPRYD7 →	-1.107	-1.654	<.001	<.001	3	8
SKIN	NDUFS1 →	-0.839	-1.102	<.001	.001	3	6
SKIN	RAB27A →	-1.974	-1.048	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	MSRB2 →	-1.212	-1.441	.001	.001	3	5
LIVER	RMDN3 →	-0.462	-1.465	.007	<.001	3	5
BLOOD_Leukemia	LTA →	+1.457	+1.114	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002062 vs SPRYD7 — OVARY

Explore this scatter interactively →