Positive regulation of mesenchymal cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of mesenchymal cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FARP1, ILK, and YARS1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mesenchymal cell proliferation activity versus FARP1 in BRCA (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FARP1 →	+0.437	+0.042	<.001	<.001	3	8
BRCA	ILK →	+0.321	+0.036	<.001	<.001	3	8
UCEC	YARS1 →	-0.213	-0.074	<.001	<.001	3	7
COAD	CASK →	+0.311	+0.054	.002	<.001	3	7
UCEC	MACROH2A2 →	+0.535	+0.078	<.001	<.001	3	7
BRCA	TLN2 →	+0.560	+0.054	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002053 vs FARP1 — BRCA

Explore this scatter interactively →