Positive regulation of mesenchymal cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of mesenchymal cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IRS2, IRS2_S560, and IRS2_S1100, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mesenchymal cell proliferation activity versus IRS2 in UCEC (Pearson r = -0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS2 →	+0.629	+0.746	<.001	<.001	3	8
CCRCC	IRS2_S560 →	+0.725	+0.582	<.001	<.001	3	8
LUAD	IRS2_S1100 →	+1.046	+0.735	<.001	<.001	3	7
LUAD	IRS2_S391 →	+0.840	+0.813	<.001	<.001	3	7
OV	IRS2_S594 →	+1.155	+1.229	<.001	<.001	3	7
CCRCC	IRS2_S736 →	+1.067	+0.817	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002053 vs IRS2 — UCEC

Explore this scatter interactively →